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Search Results for " thyroid hormone receptor, β "

Targets Recommended: Thyroid hormone receptor(THR)

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T3595	Resmetirom VIA-3196,MGL3196	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	Resmetirom (VIA-3196) 是一种高度选择性的THR-β激动剂(EC50:0.21 μM)。
T5313	Sobetirome IACS-010759,QRX-431	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	Sobetirome (IACS-010759) 是一种甲状腺激素受体 β (TRβ) 激动剂，能够选择性的结合到TRβ-1(EC50:0.16 μM)。
T79089	THR-β modulator-1
	THR-β modulator-1（compound 1a）是高效的甲状腺激素受体β（THR-β）调节剂，适用于甲状腺激素受体相关疾病的研究。
T11954	MB-07344	Others	Others
	MB-07344 has additive cholesterol lowering activity in combination with Atorvastatin in rabbits, dogs and monkeys. MB-07344 is a potent thyroid hormone receptor (TR)-β agonist with a Ki of 2.17 nM.
T63876	TRβ agonist 1
	TRβ agonist 1 为一种选择性且对突变敏感的甲状腺激素受体 β (TRβ) 激动剂，其EC50值为21 nM。该化合物适用于血脂异常、非酒精性脂肪性肝炎 (NASH) 与甲状腺激素抵抗 (RTH) 研究。
T11954L	MB-07344 sodium	Others	Others
	MB-07344 sodium has additive cholesterol lowering activity in combination with Atorvastatin in rabbits, dogs and monkeys. MB-07344 sodium is a potent thyroid hormone receptor (TR)-β agonist with a Ki of 2.17 nM.
T74785	THR-β agonist 6
	THR-β agonist 6 是一种口服活性的选择性甲状腺激素受体 β（THR-β）激动剂，其对THR-β和THR-α的EC50值分别为0.03 μM和0.22 μM，展示出93:1显著的肝血清比，在小鼠中证明其优异性。此化合物在非酒精性脂肪性肝炎（NASH）研究中显示出潜在应用价值。

化合物

Resmetirom

Cat.No: T3595

Synonym: VIA-3196,MGL3196

Target: Thyroid hormone receptor(THR)

Sobetirome

Cat.No: T5313

Synonym: IACS-010759,QRX-431

Target: Thyroid hormone receptor(THR)

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-06821	THRB Protein, Human, Recombinant (His) THRB1,GRTH,THR1,ERBA2,C-ERBA-2,THRB2,thyroid ho...	Human	E. coli
	Thyroid hormone receptor beta (THRB), also known as TRbeta and NR1A2, belongs to the nuclear hormone receptor family. Featuring an N-terminal transactivation domain, a central DNA-binding domain, and a hormone/ligand-binding domain, THRB isoform 1/2 expression localizes predominately to the liver and pituitary, respectively. THRB regulates the feedback of T3-dependent thyrotropin-stimulating hormone (TSH) transcription in the pituitary by binding to thyroid hormone (TH) response elements present...